2-hydroxy-3-oxoadipate synthase () is an enzyme that catalyzes the following chemical reaction:
The two substrates of this enzyme are α-ketoglutaric acid and glyoxylic acid. Its products are 2-hydroxy-3-oxoadipic acid and carbon dioxide. The product can spontaneously decarboxylate to give 5-hydroxy-4-oxo-pentanoic acid:
This enzyme belongs to the family of transferases, specifically those transferring aldehyde or ketonic groups (transaldolases and transketolases, respectively). Other names in common use include 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating), alpha-ketoglutaric-glyoxylic carboligase, and oxoglutarate: glyoxylate carboligase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It employs one cofactor, thiamin diphosphate.
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