Homoserine O-acetyltransferase () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme characterised from Neurospora are homoserine and acetyl-CoA. Its products are O-acetyl-homoserine and coenzyme A.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:L-homoserine O-acetyltransferase. Other names in common use include homoserine acetyltransferase, homoserine transacetylase, homoserine-O-transacetylase, and L-homoserine O-acetyltransferase. This enzyme participates in cysteine and methionine metabolism.

Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

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