In enzymology, a D-tryptophan N-malonyltransferase () is an enzyme that catalyzes the chemical reaction

malonyl-CoA + D-tryptophan CoA + N2-malonyl-D-tryptophan

Thus, the two substrates of this enzyme are malonyl-CoA and D-tryptophan, whereas its two products are CoA and N2-malonyl-D-tryptophan.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:D-tryptophan N-malonyltransferase.

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