Acetyl-CoA C-acetyltransferase () is an enzyme that catalyzes the chemical reaction
The enzyme has one substrate, acetyl-CoA, and converts two molecules of this into acetoacetyl-CoA and coenzyme A.
Acetyl-CoA C-acetyltransferase has a cysteine at its active site, and is a transferase in the group of acyltransferases which transfer groups other than aminoacyl groups. Its systematic name is acetyl-CoA:acetyl-CoA C-acetyltransferase. Other names in common use include acetoacetyl-CoA thiolase, beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA acetyltransferase, acetyl-CoA:N-acetyltransferase, and thiolase II. This enzyme participates in many metabolic pathways including fatty acid metabolism, synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, lysine degradation, tryptophan metabolism, pyruvate metabolism, propanoate metabolism, and butanoate metabolism.
Isozymes Human genes encoding acetyl-CoA C-acetyltransferases include:
References