2-ethylmalate synthase () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme characterised from Saccharomyces cerevisiae are α-ketobutyric acid, acetyl-CoA, and water. Its products are (R)-2-ethylmalic acid and coenzyme A.
This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming). Other names in common use include (R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating), 2-ethylmalate-3-hydroxybutanedioate synthase, propylmalate synthase, and propylmalic synthase.
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