2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme characterised from Escherichia coli are the (S) enantiomer of 2,3,4,5-tetrahydrodipicolinic acid (1), succinyl-CoA, and water. Its products are (S)-2-succinylamino-6-oxoheptanedioic acid (2) and coenzyme A.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. Other names in common use include tetrahydropicolinate succinylase, tetrahydrodipicolinate N-succinyltransferase, tetrahydrodipicolinate succinyltransferase, succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase, succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, and N-succinyltransferase. This enzyme participates in lysine biosynthesis.
Structural studies As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes , , , and .
References