Tezcatlipoca was an Aztec deity.

Tezcatlipoca may also refer to:

Tezcatlipoca (DC Comics), a fictional character from the DC Comics universe Tezcatlipoca (Los Comex), a character from the independent comic, El Muerto: The Aztec Zombie Tezcatlipōca (EP), an EP by Tubelord 1980 Tezcatlipoca, an asteroid, in space near Earth