Gamma-glutamyl-gamma-aminobutyrate hydrolase () is an enzyme characterised from Escherichia coli that catalyzes the hydrolysis of 4-(γ-glutamylamino)butanoic acid to γ-aminobutyric acid (GABA) and L-glutamic acid:
The reaction is part of a pathway that allows bacteria to metabolise putrescine. In potato, the enzyme regulates the amount of GABA present in response to stress.
This enzyme is a hydrolase, one acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 4-(gamma-glutamylamino)butanoate amidohydrolase. Other names in use include gamma-glutamyl-GABA hydrolase, PuuD, and YcjL.
References