Pyrimidine-5'-nucleotide nucleosidase () is an enzyme that catalyzes the general chemical reaction
a pyrimidine 5'-nucleotide + H2O D-ribose 5-phosphate + a pyrimidine base
For example, the enzyme characterised from Streptomyces species hydrolyses the nucleotide, cytidine monophosphate, to D-ribose 5-phosphate and cytosine:
The enzyme is also found in plants. It is a hydrolase, specifically a glycosylase that hydrolyses N-glycosyl compounds. The systematic name of this enzyme class is pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase. Other names in common use include pyrimidine nucleotide N-ribosidase, and Pyr5N.
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