Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

The enzyme guanosine-3′,5′-bis(diphosphate) 3′-diphosphatase (EC 3.1.7.2) catalyzes the reaction

The enzyme characterised from Escherichia coli and other bacteria hydrolyses guanosine 3',5'-bis(diphosphate) to guanosine diphosphate and pyrophosphate (PPi).

This enzyme is a hydrolase, specifically one acting on diphosphoric monoester bonds. The systematic name is guanosine-3′,5′-bis(diphosphate) 3′-diphosphohydrolase. Other names in use include guanosine-3′,5′-bis(diphosphate) 3′-pyrophosphatase, PpGpp-3'-pyrophosphohydrolase, and PpGpp phosphohydrolase.

Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References