The enzyme glutathione thiolesterase (EC 3.1.2.7) catalyzes the reaction
S-acylglutathione + H2O glutathione + a carboxylate
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is S-acylglutathione hydrolase. It is also called citryl-glutathione thioesterhydrolase.
Glutathione thiolesterase has also been found to catalyze the reaction
S-lactoylglutathione + H2O glutathione + a lactate
The catalysis of S-lactoylglutathione hydrolysis by glutathione thiolesterase has been noted in Saccharomyces cerevisiae. Additionally, human red blood cells have been found to contain at least four separate glutathione thiol esterases. The enzymes found supported the potential substrate activity of S-lactoylglutathione and S-propionylglutathione.
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