The enzyme disulfoglucosamine-6-sulfatase (EC 3.1.6.1) catalyzes the reaction
The enzyme characterised from Flavobacterium heparinum hydrolyses 2-N,6-O-disulfo-D-glucosamine (shown in its open-chain aldehydo form) to 2-N-sulfo-D-glucosamine and sulfate. The reaction is part of the breakdown of heparin.
This enzyme is a hydrolase, specifically one acting on sulfuric ester bonds. The systematic name is 2-N,6-O-disulfo-D-glucosamine 6-sulfohydrolase. Other names in common use include N-sulfoglucosamine-6-sulfatase, and 6,N-disulfoglucosamine 6-O-sulfohydrolase.
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