The enzyme [acyl-carrier-protein] phosphodiesterase (EC 3.1.4.14) catalyzes the reaction
holo-[acyl-carrier-protein] + HO 4-phosphopantetheine + apo-[acyl-carrier-protein]
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name is holo-[acyl-carrier-protein] 4-pantetheine-phosphohydrolase. Other names in common use include ACP hydrolyase, ACP phosphodiesterase, AcpH, and [acyl-carrier-protein] 4-pantetheine-phosphohydrolase. This enzyme participates in pantothenate and CoA biosynthesis.
ACP hydrolyase and ACP hydrolyase homologues are related to the hydrolyase domain of the bacterial protein SpoT. AcpH hydrolyzes the link between acyl carrier protein's serine-36 side chain and 4'-phosphopanthetheine.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .
References