The enzyme acetoacetyl-CoA hydrolase (EC 3.1.2.11) catalyzes the reaction
The enzyme characterised from liver hydrolyses acetoacetyl-CoA to coenzyme A and acetoacetic acid, which forms the thioester in the starting material. The enzyme from Thermosipho melanesiensis has been studied as a means of producing acetone by metabolic engineering.
This is a hydrolase, specifically one acting on thioester bonds. The systematic name is acetoacetyl-CoA hydrolase. Other names in common use include acetoacetyl coenzyme A hydrolase, acetoacetyl CoA deacylase, and acetoacetyl coenzyme A deacylase.
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