The enzyme 2′,3′-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16) catalyzes the general reaction
nucleoside 2′,3′-cyclic phosphate + H2O nucleoside 3′-phosphate
For example, the enzyme characterised from Escherichia coli, 2',3'-cyclic AMP is hydrolysed to 3'-adenylic acid:
Similar activity has been found in preparations from Proteus mirabilis, bovine brain, and Vibrio alginolyticus.
This enzyme is a hydrolase, specifically one acting on phosphoric diester bonds. The systematic name is nucleoside-2′,3′-cyclic-phosphate 3'-nucleotidohydrolase. Other names in use include ribonucleoside 2′,3′-cyclic phosphate diesterase, 2′,3′-cyclic AMP phosphodiesterase, 2′,3′-cyclic nucleotidase, cyclic 2′,3′-nucleotide 2′-phosphodiesterase, cyclic 2′,3′-nucleotide phosphodiesterase, 2′,3′-cyclic nucleoside monophosphate phosphodiesterase, 2′,3′-cyclic AMP 2′-phosphohydrolase, cyclic phosphodiesterase:3′-nucleotidase, 2′,3′-cyclic nucleotide phosphohydrolase, 2′:3′-cyclic phosphodiesterase, and 2′:3′-cyclic nucleotide phosphodiesterase:3'-nucleotidase.
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