Adhesion G protein-coupled receptor A1 is a protein that in humans is encoded by the ADGRA1 gene (previously GPR123). It is an orphan receptor which is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

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