Sphingosine-1-phosphate receptor 2, also known as S1PR2 or S1P2, is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).
Function
This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation. It has also been shown to interact with Nogo-A (RTN4), an neurite outgrowth inhibitor. S1PR2 is expressed in neuronal and vascular cells and is crucial for the migration and growth of developing and injured neuronal and vascular system.
Evolution
Paralogues Source: S1PR1 S1PR3 S1PR5 S1PR4 LPAR2 LPAR1 LPAR3 CNR1 GPR6 MC3R GPR12 GPR3 MC4R MC1R CNR2 MC5R MC2R GPR119
See also Lysophospholipid receptor
References
Further reading
External links