Hypocretin (orexin) receptor 1

Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene.

Function

The orexin 1 receptor (OX1), is a G-protein coupled receptor that is heavily expressed in projections from the lateral hypothalamus and is involved in the regulation of feeding behaviour. OX1 selectively binds the orexin-A neuropeptide. It shares 64% identity with OX2.

Ligands

Agonists Orexin-A

Antagonists

ACT-335827 – selective OX1 antagonist Almorexant – dual OX1 and OX2 antagonist Lemborexant – dual OX1 and OX2 antagonist Nemorexant – dual OX1 and OX2 antagonist Rocavorexant (C4X-3256; INDV-2000) – selective OX1 receptor antagonist RTIOX-276 – selective OX1 antagonist SB-334,867 – selective OX1 antagonist SB-408,124 – selective OX1 antagonist SB-649,868 – dual OX1 and OX2 antagonist Suvorexant – dual OX1 and OX2 antagonist

See also Orexin receptor

References

Further reading

External links