The following highways are numbered 259:
Brazil BR-259
Canada Manitoba Provincial Road 259 Prince Edward Island Route 259 Quebec Route 259
Japan Japan National Route 259
United Kingdom road B259 road
United States
U.S. Route 259 Alabama State Route 259 California State Route 259 Florida State Road 259 (former) Georgia State Route 259 (former) Iowa Highway 259 (former) Kentucky Route 259 Maryland Route 259 Minnesota State Highway 259 (former) Montana Secondary Highway 259 New York State Route 259 Oklahoma State Highway 259A Pennsylvania Route 259 Tennessee State Route 259 Texas State Highway 259 (former) Utah State Route 259 Virginia State Route 259 West Virginia Route 259 Wyoming Highway 259