GPR6

G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.

Function

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active. It was previously thought to also act as a sphingosine-1-phosphate receptor, but this was found to not be the case in later research.

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.

Ligand

Inverse Agonist Cannabidiol Solangepras (solengepras; CVN-424)

Evolution

Paralogues to GPR6 gene

Source:

GPR3 GPR12 S1PR5 S1PR1 CNR1 S1PR2 LPAR2 CNR2 MC1R S1PR3 S1PR4 GPR119 MC3R MC4R MC5R LPAR1 LPAR3 MC2R

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