William Drake may refer to:
Arts and entertainment William Henry Drake (painter) (1886–1926), American painter and illustrator William A. Drake (1899–1965), American screenwriter Bill Drake (1937–2008), American radio programmer William D. Drake (born 1962), British musician
Politics and law Sir William Drake, 1st Baronet (1606–1669), English lawyer and Member of Parliament Sir William Drake (died 1690) (c. 1651–1690), English Member of Parliament for Amersham, 1669–1690 Sir William Drake, 4th Baronet (1658–1716), English Member of Parliament William Drake (1723–1796) (senior), English Member of Parliament for Amersham, 1746–1796 William Drake (1747–1795) (junior), English Member of Parliament for Amersham, 1768
Other William Drake (antiquary) (1723–1801), Church of England priest, antiquary and philologist William Henry Drake (1812–1882), British public servant and colonial treasurer of Western Australia William Tasman Drake (1884–1946), New Zealand clergyman and cricketer Bill Drake (baseball) (1895–1977), American Negro league baseball player Bill Drake (American football) (1950-2018), American football player Billy Drake (1917–2011), British RAF pilot Bill Drake (rugby league) (1931–2012), English rugby league footballer William Drake (organ builder) (1943–2014), British organ builder
See also William Tyrwhitt-Drake (1785–1848), Tory English Member of Parliament for Amersham from 1810 William Drake Westervelt (1849–1939), writer on Hawaiian history and legends