Hube is a surname and given name. As a surname, it can also be spelled "Hübe" (German).

Notable people with the surname include:

Constanza Hube (born 1987), Chilean lawyer Douglas P. Hube (born 1941), Canadian astronomer Florian Hube (born 1980), German football player Hans-Valentin Hube (1890–1944), German soldier Jörg Hube (1943–2009), German actor and director Michał Jan Hube (1737–1807), Polish physicist and educator Rick Hube (1947–2009), Vermont politician Romuald Hube (1803–1890), Polish law scholar

Notable people with the given name include:

Hube Wagner (1891–1979), American football player