Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene. As one of the 3 Gi alpha subunits, this protein has an important role in inhibitory cell signaling for many hormones and neurotransmitters, such as adrenaline and noradrenaline (as part of beta adrenergic receptor signaling). Mutations in the gene can lead to a disorder called NEDHISB (which stands for Neurodevelopmental Disorder with Hypotonia, Impaired Speech, and Behavioral Abnormalities).
Interactive pathway map
Interactions
GNAI1 has been shown to interact with:
GPR143, RGS12, RGS14, RGS19, RIC8A, and S1PR1.
References
Further reading