In enzymology, a histidine–tRNA ligase () is an enzyme that catalyzes the chemical reaction
ATP + -histidine + tRNA AMP + diphosphate + -histidyl-tRNA
The 3 substrates of this enzyme are ATP, -histidine, and tRNA, whereas its 3 products are AMP, diphosphate, and -histidyl-tRNA.
This enzyme participates in histidine metabolism and aminoacyl-tRNA biosynthesis.
Nomenclature
Histidine–tRNA ligase belongs to the family of ligase enzymes, specifically those forming carbon–oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is -histidine:tRNA ligase (AMP-forming). Other names in common use include histidyl-tRNA synthetase, histidyl-transfer ribonucleate synthetase, and histidine translase.
See also Anti-Jo1 Histidine–tRNA ligase, cytoplasmic Histidine–tRNA ligase, mitochondrial
References