In enzymology, a glutamate—methylamine ligase () is an enzyme that catalyzes the chemical reaction
ATP + L-glutamate + methylamine ADP + phosphate + N5-methyl-L-glutamine
The 3 substrates of this enzyme are ATP, L-glutamate, and methylamine, whereas its 3 products are ADP, phosphate, and N5-methyl-L-glutamine.
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is L-glutamate:methylamine ligase (ADP-forming). This enzyme is also called gamma-glutamylmethylamide synthetase.
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