Butyrate—CoA ligase, also known as xenobiotic/medium-chain fatty acid-ligase (XM-ligase), is an enzyme () that catalyzes the chemical reaction: ATP + a carboxylic acid + CoA AMP + diphosphate + an acyl-CoA
The 3 substrates of this enzyme are ATP, carboxylic acid, and CoA, whereas its 3 products are AMP, diphosphate, and acyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. This enzyme participates in the glycine conjugation of xenobiotics and butanoate metabolism.
Nomenclature
The systematic name of this enzyme class is butanoate:CoA ligase (AMP-forming). Other names in common use include: butyryl-CoA synthetase, fatty acid thiokinase (medium chain), acyl-activating enzyme, fatty acid elongate, fatty acid activating enzyme, fatty acyl coenzyme A synthetase, medium chain acyl-CoA synthetase, butyryl-coenzyme A synthetase, L-(+)-3-hydroxybutyryl CoA ligase, xenobiotic/medium-chain fatty acid ligase, and short-chain acyl-CoA synthetase.
Human proteins containing this domain ACSM1 ACSM2A ACSM2B ACSM3 ACSM4 ACSM5 ACSM6
References