D-alanine 2-hydroxymethyltransferase () is an enzyme that catalyzes the chemical reaction
This tetrahydrofolate–dependent enzyme catalyzes a reversible substitution of the formyl group from the cofactor 10-methylenetetrahydrofolate (5,10-CH2-THF) to D-alanine to give 2-methyl-L-serine and tetrahydrofolic acid (THF).
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase. This enzyme is also called 2-methylserine hydroxymethyltransferase. This enzyme participates in the one carbon pool by folate.
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