The enzyme glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) catalyzes the reaction
6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 6-(α-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase [6-(α-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming].
Other names in common use include:
GPI-PLC GPI-specific phospholipase C Glycosyl inositol phospholipid anchor-hydrolyzing enzyme Glycosylphosphatidylinositol-phospholipase C Glycosylphosphatidylinositol-specific phospholipase C or VSG-lipase Variant-surface-glycoprotein phospholipase C 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol Diacylglycerol-lyase (1,2-cyclic-phosphate-forming)
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