Isochorismatase () is an enzyme that catalyzes the chemical reaction
The enzyme characterised from Aerobacter aerogenes and Escherichia coli hydrolyses isochorismic acid to (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoic acid and pyruvic acid, as part of the biosynthesis of siderophores such as enterobactin. 2,3-Dihydroxybenzoic acid is a competitive inhibitor of the enzyme.
This enzyme is a hydrolase, specifically one acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is isochorismate pyruvate-hydrolase. Other names in common use include 2,3-dihydro-2,3-dihydroxybenzoate synthase, 2,3-dihydroxy-2,3-dihydrobenzoate synthase, and 2,3-dihydroxy-2,3-dihydrobenzoic synthase.
Structural studies As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and .
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