James Mathews may refer to:
James Mathews (American politician) (1805–1887), member of the US House of Representatives from Ohio James Mathews (Australian politician) (1865–1934), Australian politician James Mathews (rugby league) (1968–1992), Australian rugby player James M. Mathews, Chancellor of New York University (NYU) James McFarlane Mathews (1785–1870), American clergyman in New York City
See also James Mathew (born 1961), Indian politician James Matthews (disambiguation)