In enzymology, a Methanosarcina-phenazine hydrogenase () is an enzyme that catalyzes the chemical reaction

H2 + 2-(2,3-dihydropentaprenyloxy)phenazine 2-dihydropentaprenyloxyphenazine

Thus, the two substrates of this enzyme are H2 and 2-(2,3-dihydropentaprenyloxy)phenazine, whereas its product is 2-dihydropentaprenyloxyphenazine.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with other, known, acceptors. The systematic name of this enzyme class is hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase. Other names in common use include methanophenazine hydrogenase, and methylviologen-reducing hydrogenase.

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