In enzymology, D-sorbitol dehydrogenase (acceptor) () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are D-sorbitol and an electron acceptor. Its products are L-sorbose (shown in open-chain keto form) and the corresponding reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is D-sorbitol:acceptor 1-oxidoreductase. This enzyme is also called D-sorbitol:(acceptor) 1-oxidoreductase. This enzyme participates in fructose and mannose metabolism. It employs one cofactor, FAD.
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