Guene may refer to:
Guénè, Benin Guene language, a secret language among the slaves of West Curaçao, which may have influenced Papiamento
People with the surname Guene include: Charles Guené (born 1952), French politician Faïza Guène (born 1985), French writer and director Mantoulaye Guene (1939–1991), Senegalese teacher and politician
See also Güeñes, Spain