Scruff may refer to:
Scruff (anatomy), a loose, non-sensitive area of skin by which a mother can carry her young Scruff (app), a mobile application for gay men Scruff (TV series), a Spanish children's animated television series Scruff Connors (1952–2016), Canadian radio broadcaster Mr. Scruff (born 1972), British DJ and artist
See also Scruffy (disambiguation) The Scruffs