James McGuinness may refer to:
James Kevin McGuinness (1893–1950), American screenwriter and film produce James McGuinness (bishop) (1925–2007), Roman Catholic bishop of the Diocese of Nottingham Martin McGuinness (James Martin Pacelli McGuinness, 1950–2017), Irish Sinn Féin politician and deputy First Minister of Northern Ireland
See also Jim McGuinness (born 1972), Gaelic footballer Jay McGuiness (born 1990), English singer and member of The Wanted