Trans-cinnamate 4-monooxygenase () is an enzyme that catalyzes the chemical reaction
The four substrates of this enzyme are cinnamic acid, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. Its products are p-coumaric acid, oxidised NADP+, and water. It participates in phenylalanine metabolism and phenylpropanoid biosynthesis, especially of flavonoids in plants.
The enzyme is a cytochrome P450 protein containing heme. It requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate (NADPH).
Nomenclature The systematic name of this enzyme class is trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating). Other names in common use include:
cinnamic acid 4-hydroxylase, oxygenase, cinnamate 4-mono-, CA4H (gene name), CYP73A1 (gene name), cytochrome P450 cinnamate 4-hydroxylase, cinnamate 4-hydroxylase, cinnamate 4-monooxygenase, cinnamate hydroxylase, cinnamic 4-hydroxylase, cinnamic acid 4-monooxygenase, cinnamic acid p-hydroxylase, hydroxylase, cinnamate 4-, t-cinnamic acid hydroxylase, trans-cinnamate 4-hydroxylase, and trans-cinnamic acid 4-hydroxylase.
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