Tetrachloroethene reductive dehalogenase (, previously 1.97.1.8) is an enzyme that catalyzes some chemical reactions which allow bacteria to metabolise chlorinated hydrocarbons. For example, Dehalobacter restrictus converts tetrachloroethylene to trichloroethylene:
The enzyme can also convert trichloroethylene into dichloroethylene and requires an electron acceptor, which is believed to be menaquinone.
This enzyme is an oxidoreductase with systematic name acceptor:trichloroethene oxidoreductase (chlorinating). This enzyme is also called tetrachloroethene reductase. It is one member of a family of enzymes including trichloroethene dehalogenase and vinyl chloride dehalogenase. Reductive dehalogenases are key enzymes for anaerobic respiratory process, termed organohalide respiration, and hence can be used for bioremediation.
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