Nicotinate N-methyltransferase () is an enzyme that catalyzes the chemical reaction
The enzyme catalyses a methylation reaction in which nicotinic acid is converted to trigonelline (N-methylnicotinate). The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which loses its methyl group and becomes S-adenosyl-L-homocysteine (SAH).
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:nicotinate N-methyltransferase. Other names in common use include furanocoumarin 8-methyltransferase, and furanocoumarin 8-O-methyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism.
Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .
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