Indolepyruvate C-methyltransferase () is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which indole-3-pyruvic acid is converted to (R)-3-(indol-3-yl)-2-oxobutyric acid. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH).
This enzyme is part of the biosynthetic pathway to the indole alkaloid, indolmycin, in Streptomyces griseus
Nomenclature This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine: (indol-3-yl)pyruvate C-methyltransferase. Other names in common use include indolepyruvate methyltransferase, indolepyruvate 3-methyltransferase, indolepyruvic acid methyltransferase, and S-adenosyl-L-methionine:indolepyruvate C-methyltransferase.
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