Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene. It is also known as HPK1 (Hematopoietic Progenitor Kinase 1). The protein has been shown to play a role in JNK activation.
Interactions
MAP4K1 has been shown to interact with:
B-cell linker, CRK, CRKL, Drebrin-like, GRAP2, Grb2, Linker of activated T cells, and NCK1.
Optimization of inhibitors of MAP4K1 for upregulating the T cell receptor signaling pathway has produced at least one compound that exhibits antitumor activity in an EMT6 syngeneic mouse model, and is an area of ongoing research.
References