The Great Northern Depot or Great Northern Passenger Depot may refer to:

Minnesota Great Northern Passenger Depot (Alexandria, Minnesota) Great Northern Depot (Bemidji, Minnesota) Minneapolis Great Northern Depot, Minneapolis, Minnesota Great Northern Depot (Princeton, Minnesota) Great Northern Depot (Wayzata, Minnesota)

Mississippi New Orleans Great Northern Railroad Passenger Depot, a National Register of Historic Places listing in Hinds County, Mississippi New Orleans Great Northern Railroad Depot, a National Register of Historic Places listing in Lawrence County, Mississippi New Orleans and Great Northern Railroad Depot-Tylertown, a National Register of Historic Places listing in Walthall County, Mississippi

Montana Great Northern Railway Depot (Butte, Montana), currently a bar and night club in Butte, Montana Great Northern Railway Depot (Kalispell, Montana), a National Register of Historic Places listing in Flathead County, Montana Great Northern Railway Passenger and Freight Depot and Division Office, Whitefish, Montana

North Dakota Great Northern Passenger Depot - Fargo Great Northern Freight Warehouse and Depot, Grand Forks, North Dakota Great Northern Railway Depot (Mayville, North Dakota) Great Northern Passenger Depot (Rugby, North Dakota) Great Northern Railway Underpass, Stanley, North Dakota

South Dakota Great Northern Railway Passenger and Freight Depot

Texas International & Great Northern Railroad Passenger Depot, a National Register of Historic Places listing in Milam County, Texas International & Great Northern Railroad Passenger Station, a National Register of Historic Places listing in Bexar County, Texas

Washington Great Northern Depot (Anacortes, Washington), a National Register of Historic Places listing in Skagit County, Washington Great Northern Passenger Station (Bellingham, Washington), a National Register of Historic Places listing in Whatcom County, Washington Great Northern Depot (Skykomish, Washington)

See also Great Northern Railway Steam Locomotive No. 1355 and Tender 1451, Sioux City, Iowa Great Northern Railway Company Bridge, Cass Lake, Minnesota, a National Register of Historic Places listing in Cass County, Minnesota Great Northern Implement Company, Minneapolis, Minnesota Great Northern Railway Buildings, Glacier National Park, Montana Great Northern Freight Warehouse, Fargo, North Dakota