Duane is a surname. Notable persons with that surname include:
Anthony Duane (1679–1747), Irish born American settler, father of James Duane Diane Duane (born 1952), American science fiction and fantasy author Iris Duane, Scottish politician James Duane (1733–1797), American lawyer, jurist, Continental Congressman, Revolutionary leader, and Mayor of New York City James Joseph Duane (born 1959), American legal academic James Chatham Duane (1824–1897), American engineering officer in the Union Army during the American Civil War Michael Duane (1915–1997), Irish-born British progressive educationalist and headteacher Ronnie Duane, rugby league footballer of the 1980s and 1990s Thomas Duane (born 1955), American member of the New York State Senate William Duane (physicist) (1872–1935), American physicist William John Duane (1780–1865), Irish born American politician and lawyer