In enzymology, an uronate dehydrogenase () is an enzyme that catalyzes the chemical reaction
D-galacturonate + NAD+ + H2O + NADH + H+
The 3 substrates of this enzyme are D-galacturonate, NAD+, and H2O, whereas its 3 products are (the lactone of D-galactarate), NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is uronate:NAD+ 1-oxidoreductase. Other names in common use include uronate: NAD-oxidoreductase, and uronic acid dehydrogenase.
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