In enzymology, methylglyoxal reductase (NADPH-dependent) () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are (S)-lactaldehyde and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are methylglyoxal, reduced NADPH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is lactaldehyde:NADP+ oxidoreductase. Other names in common use include lactaldehyde dehydrogenase (NADP+), and Gre2.
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