In enzymology, a malate dehydrogenase (oxaloacetate-decarboxylating) () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are (S)-malic acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are pyruvic acid, carbon dioxide, and reduced NADH.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating). Other names in common use include malic enzyme, pyruvic-malic carboxylase, NAD+-specific malic enzyme, NAD+-malic enzyme, and NAD+-linked malic enzyme. This enzyme participates in pyruvate metabolism.
Structural studies As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , and .
See also ME2 (gene) Malate dehydrogenase (decarboxylating) which performs the same reaction
References