In enzymology, cyclopentanol dehydrogenase () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are cyclopentanol and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are cyclopentanone, reduced NADH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cyclopentanol:NAD+ oxidoreductase.

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