In enzymology, an acetoacetyl-CoA reductase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are the (R) isomer of a 3-hydroxyacyl derivative of coenzyme A and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are the corresponding 3-oxoacyl derivative of the coenzyme, reduced NADPH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase. Other names in common use include acetoacetyl coenzyme A reductase, hydroxyacyl coenzyme-A dehydrogenase, NADP+-linked acetoacetyl CoA reductase, NADPH:acetoacetyl-CoA reductase, D(−)-beta-hydroxybutyryl CoA-NADP+ oxidoreductase, short chain beta-ketoacetyl(acetoacetyl)-CoA reductase, beta-ketoacyl-CoA reductase, D-3-hydroxyacyl-CoA reductase, and (R)-3-hydroxyacyl-CoA dehydrogenase. This enzyme participates in butanoate metabolism.
See also 3-hydroxyacyl-CoA dehydrogenase operating on the enantiomer of the substrate
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