The Pittsburgh Pirates played their 40th season in 1921. It was their 35th season in the National League. The Pirates finished second in the league standings with a record of 90–63. It was the first season in which games were aired on radio via the then new station KDKA to listeners all over Pittsburgh, making that team the first in MLB to employ radio broadcasters for game broadcasts on the then new medium.
Regular season
Season standings
Record vs. opponents
Game log
|- bgcolor="ffbbbb" | 1 || April 13 || @ Reds || 3–5 || Luque || Adams (0–1) || — || 30,444 || 0–1 |- bgcolor="ccffcc" | 2 || April 14 || @ Reds || 7–2 || Cooper (1–0) || Marquard || — || — || 1–1 |- bgcolor="ccffcc" | 3 || April 15 || @ Reds || 3–1 || Hamilton (1–0) || Rixey || Yellow Horse (1) || — || 2–1 |- bgcolor="ccffcc" | 4 || April 16 || @ Reds || 7–3 || Ponder (1–0) || Brenton || — || — || 3–1 |- bgcolor="ffbbbb" | 5 || April 18 || @ Cubs || 4–7 || Tyler || Zinn (0–1) || — || — || 3–2 |- bgcolor="ccffcc" | 6 || April 19 || @ Cubs || 14–2 || Hamilton (2–0) || Martin || — || — || 4–2 |- bgcolor="ccffcc" | 7 || April 20 || @ Cubs || 6–5 || Carlson (1–0) || Freeman || Glazner (1) || — || 5–2 |- bgcolor="ccffcc" | 8 || April 21 || Reds || 8–7 || Yellow Horse (1–0) || Brenton || — || — || 6–2 |- bgcolor="ccffcc" | 9 || April 22 || Reds || 6–1 || Zinn (1–1) || Luque || — || — || 7–2 |- bgcolor="ffbbbb" | 10 || April 23 || Reds || 4–5 || Marquard || Hamilton (2–1) || — || — || 7–3 |- bgcolor="ccffcc" | 11 || April 24 || @ Reds || 7–2 || Adams (1–1) || Rixey || — || — || 8–3 |- bgcolor="ccffcc" | 12 || April 25 || @ Cardinals || 6–5 (10) || Ponder (2–0) || Pertica || — || — || 9–3 |- bgcolor="ccffcc" | 13 || April 27 || @ Cardinals || 7–4 || Hamilton (3–1) || May || Zinn (1) || — || 10–3 |- bgcolor="ccffcc" | 14 || April 29 || Cubs || 3–0 || Cooper (2–0) || York || — || — || 11–3
|- bgcolor="ccffcc" | 15 || May 1 || @ Cubs || 2–0 || Adams (2–1) || Vaughn || — || — || 12–3 |- bgcolor="ccffcc" | 16 || May 2 || @ Cubs || 4–3 || Glazner (1–0) || Martin || — || — || 13–3 |- bgcolor="ccffcc" | 17 || May 5 || Cardinals || 8–3 || Cooper (3–0) || Pertica || — || — || 14–3 |- bgcolor="ccffcc" | 18 || May 6 || Cardinals || 10–6 || Hamilton (4–1) || Haines || Zinn (2) || — || 15–3 |- bgcolor="ccffcc" | 19 || May 7 || Cardinals || 2–1 || Glazner (2–0) || Sherdel || — || — || 16–3 |- bgcolor="ffbbbb" | 20 || May 8 || @ Reds || 0–1 || Rixey || Adams (2–2) || — || — || 16–4 |- bgcolor="ccffcc" | 21 || May 10 || @ Braves || 5–2 || Cooper (4–0) || Oeschger || — || — || 17–4 |- bgcolor="ffbbbb" | 22 || May 11 || @ Braves || 0–1 (13) || Fillingim || Hamilton (4–2) || — || — || 17–5 |- bgcolor="ccffcc" | 23 || May 12 || @ Braves || 3–1 || Glazner (3–0) || Watson || — || — || 18–5 |- bgcolor="ccffcc" | 24 || May 14 || @ Phillies || 6–4 (10) || Cooper (5–0) || Smith || — || — || 19–5 |- bgcolor="ffbbbb" | 25 || May 16 || @ Phillies || 0–3 || Causey || Hamilton (4–3) || Ring || — || 19–6 |- bgcolor="ccffcc" | 26 || May 17 || @ Phillies || 6–4 || Glazner (4–0) || Hubbell || — || — || 20–6 |- bgcolor="ccffcc" | 27 || May 18 || @ Robins || 11–2 || Cooper (6–0) || Ruether || — || 10,000 || 21–6 |- bgcolor="ccffcc" | 28 || May 19 || @ Robins || 7–5 || Adams (3–2) || Smith || — || 10,000 || 22–6 |- bgcolor="ccffcc" | 29 || May 20 || @ Robins || 3–2 || Hamilton (5–3) || Cadore || — || 8,000 || 23–6 |- bgcolor="ccffcc" | 30 || May 21 || @ Robins || 13–6 || Zinn (2–1) || Mitchell || Carlson (1) || 20,000 || 24–6 |- bgcolor="ccffcc" | 31 || May 22 || @ Giants || 8–6 || Cooper (7–0) || Sallee || — || 40,000 || 25–6 |- bgcolor="ffbbbb" | 32 || May 24 || @ Giants || 3–5 || Nehf || Adams (3–3) || — || — || 25–7 |- bgcolor="ffbbbb" | 33 || May 26 || Reds || 1–4 || Marquard || Hamilton (5–4) || — || — || 25–8 |- bgcolor="ccffcc" | 34 || May 27 || Reds || 5–4 || Cooper (8–0) || Rixey || — || — || 26–8 |- bgcolor="ccffcc" | 35 || May 28 || Reds || 4–3 || Adams (4–3) || Luque || — || — || 27–8 |- bgcolor="ffbbbb" | 36 || May 29 || @ Reds || 3–4 (13) || Rixey || Carlson (1–1) || — || — || 27–9 |- bgcolor="ccffcc" | 37 || May 30 || Cubs || 13–0 || Zinn (3–1) || York || — || — || 28–9 |- bgcolor="ccffcc" | 38 || May 30 || Cubs || 6–3 || Yellow Horse (2–0) || Tyler || — || — || 29–9 |- bgcolor="ffbbbb" | 39 || May 31 || Cubs || 6–7 (12) || Freeman || Hamilton (5–5) || — || — || 29–10
|- bgcolor="ccffcc" | 40 || June 1 || Cubs || 4–2 || Glazner (5–0) || Martin || — || — || 30–10 |- bgcolor="ffbbbb" | 41 || June 2 || Giants || 0–7 || Nehf || Zinn (3–2) || — || 20,000 || 30–11 |- bgcolor="ffbbbb" | 42 || June 3 || Giants || 1–4 || Toney || Hamilton (5–6) || — || 15,000 || 30–12 |- bgcolor="ffbbbb" | 43 || June 4 || Giants || 0–12 || Douglas || Cooper (8–1) || — || 25,000 || 30–13 |- bgcolor="ccffcc" | 44 || June 6 || Giants || 5–4 || Adams (5–3) || Barnes || — || 9,000 || 31–13 |- bgcolor="ffbbbb" | 45 || June 7 || Braves || 7–10 || Oeschger || Yellow Horse (2–1) || — || — || 31–14 |- bgcolor="ccffcc" | 46 || June 8 || Braves || 16–4 || Hamilton (6–6) || McQuillan || — || — || 32–14 |- bgcolor="ccffcc" | 47 || June 9 || Braves || 5–3 || Cooper (9–1) || Fillingim || — || — || 33–14 |- bgcolor="ffbbbb" | 48 || June 10 || Braves || 1–4 || Scott || Glazner (5–1) || — || — || 33–15 |- bgcolor="ccffcc" | 49 || June 11 || Phillies || 10–3 || Adams (6–3) || Hubbell || — || — || 34–15 |- bgcolor="ccffcc" | 50 || June 13 || Phillies || 12–5 || Hamilton (7–6) || Baumgartner || — || — || 35–15 |- bgcolor="ccffcc" | 51 || June 14 || Phillies || 8–3 || Zinn (4–2) || Ring || — || — || 36–15 |- bgcolor="ffbbbb" | 52 || June 15 || Robins || 3–7 || Grimes || Cooper (9–2) || — || 7,000 || 36–16 |- bgcolor="ccffcc" | 53 || June 16 || Robins || 6–5 (17) || Yellow Horse (3–1) || Mamaux || — || 5,000 || 37–16 |- bgcolor="ffbbbb" | 54 || June 17 || Robins || 3–8 || Cadore || Hamilton (7–7) || — || 8,000 || 37–17 |- bgcolor="ccffcc" | 55 || June 18 || Robins || 4–3 || Cooper (10–2) || Ruether || — || 18,000 || 38–17 |- bgcolor="ccffcc" | 56 || June 20 || Phillies || 3–2 || Yellow Horse (4–1) || Meadows || Zinn (3) || — || 39–17 |- bgcolor="ccffcc" | 57 || June 22 || @ Reds || 5–2 (12) || Cooper (11–2) || Rixey || — || — || 40–17 |- bgcolor="ffbbbb" | 58 || June 23 || @ Cardinals || 2–3 (12) || Walker || Carlson (1–2) || — || — || 40–18 |- bgcolor="ffbbbb" | 59 || June 23 || @ Cardinals || 3–4 || Doak || Zinn (4–3) || — || — || 40–19 |- bgcolor="ccffcc" | 60 || June 24 || @ Cardinals || 4–3 (10) || Glazner (6–1) || Bailey || — || — || 41–19 |- bgcolor="ffbbbb" | 61 || June 25 || @ Cardinals || 4–7 || Pfeffer || Yellow Horse (4–2) || North || — || 41–20 |- bgcolor="ccffcc" | 62 || June 25 || @ Cardinals || 5–2 || Cooper (12–2) || Pertica || — || — || 42–20 |- bgcolor="ccffcc" | 63 || June 26 || @ Cubs || 11–3 || Adams (7–3) || Alexander || — || — || 43–20 |- bgcolor="ccffcc" | 64 || June 27 || @ Cubs || 10–3 || Morrison (1–0) || Vaughn || — || — || 44–20 |- bgcolor="ffbbbb" | 65 || June 28 || @ Cubs || 1–2 || Martin || Zinn (4–4) || — || — || 44–21 |- bgcolor="ffbbbb" | 66 || June 28 || @ Cubs || 6–8 || Tyler || Carlson (1–3) || — || — || 44–22 |- bgcolor="ccffcc" | 67 || June 29 || @ Cubs || 3–1 || Cooper (13–2) || Cheeves || — || — || 45–22 |- bgcolor="ccffcc" | 68 || June 30 || Reds || 5–3 || Yellow Horse (5–2) || Luque || — || — || 46–22
|- bgcolor="ccffcc" | 69 || July 1 || Reds || 5–2 || Morrison (2–0) || Rixey || — || — || 47–22 |- bgcolor="ccffcc" | 70 || July 2 || Reds || 9–0 || Adams (8–3) || Brenton || — || — || 48–22 |- bgcolor="ffbbbb" | 71 || July 3 || @ Reds || 2–8 || Marquard || Hamilton (7–8) || — || — || 48–23 |- bgcolor="ccffcc" | 72 || July 4 || Cardinals || 5–2 || Glazner (7–1) || Bailey || — || — || 49–23 |- bgcolor="ffbbbb" | 73 || July 4 || Cardinals || 3–6 || Pertica || Cooper (13–3) || — || — || 49–24 |- bgcolor="ffbbbb" | 74 || July 5 || Cardinals || 2–8 || Walker || Yellow Horse (5–3) || — || — || 49–25 |- bgcolor="ccffcc" | 75 || July 6 || Cardinals || 3–2 (13) || Morrison (3–0) || North || — || — || 50–25 |- bgcolor="ccffcc" | 76 || July 8 || @ Robins || 5–3 || Cooper (14–3) || Schupp || — || — || 51–25 |- bgcolor="ccffcc" | 77 || July 9 || @ Robins || 4–2 || Glazner (8–1) || Cadore || — || 8,000 || 52–25 |- bgcolor="ffbbbb" | 78 || July 10 || @ Robins || 3–7 || Grimes || Morrison (3–1) || — || 10,000 || 52–26 |- bgcolor="ffbbbb" | 79 || July 11 || @ Robins || 8–9 || Miljus || Hamilton (7–9) || — || 8,000 || 52–27 |- bgcolor="ccffcc" | 80 || July 12 || @ Phillies || 9–4 || Cooper (15–3) || Baumgartner || — || — || 53–27 |- bgcolor="ccffcc" | 81 || July 14 || @ Phillies || 5–4 (10) || Carlson (2–3) || Ring || — || — || 54–27 |- bgcolor="ffbbbb" | 82 || July 16 || @ Giants || 4–13 || Douglas || Cooper (15–4) || — || 33,000 || 54–28 |- bgcolor="ccffcc" | 83 || July 17 || @ Giants || 4–2 (10) || Hamilton (8–9) || Causey || — || 36,000 || 55–28 |- bgcolor="ffbbbb" | 84 || July 18 || @ Giants || 1–12 || Nehf || Morrison (3–2) || — || 10,000 || 55–29 |- bgcolor="ccffcc" | 85 || July 19 || @ Giants || 10–1 || Adams (9–3) || Ryan || — || 18,000 || 56–29 |- bgcolor="ccffcc" | 86 || July 20 || @ Braves || 2–0 || Cooper (16–4) || Oeschger || — || — || 57–29 |- bgcolor="ffbbbb" | 87 || July 22 || @ Braves || 1–2 (10) || McQuillan || Hamilton (8–10) || — || — || 57–30 |- bgcolor="ccffcc" | 88 || July 22 || @ Braves || 4–3 (13) || Glazner (9–1) || Fillingim || — || — || 58–30 |- bgcolor="ccffcc" | 89 || July 23 || @ Braves || 3–2 || Cooper (17–4) || Watson || — || — || 59–30 |- bgcolor="ffbbbb" | 90 || July 23 || @ Braves || 1–3 || Scott || Carlson (2–4) || — || — || 59–31 |- bgcolor="ccffcc" | 91 || July 25 || Giants || 6–3 || Adams (10–3) || Douglas || — || 20,000 || 60–31 |- bgcolor="ffbbbb" | 92 || July 26 || Giants || 8–9 (10) || Barnes || Glazner (9–2) || — || 15,000 || 60–32 |- bgcolor="ffbbbb" | 93 || July 27 || Giants || 1–4 || Nehf || Cooper (17–5) || — || — || 60–33 |- bgcolor="ffbbbb" | 94 || July 28 || Giants || 4–6 || Douglas || Glazner (9–3) || Ryan || 15,000 || 60–34 |- bgcolor="ffbbbb" | 95 || July 30 || Braves || 0–1 || Oeschger || Cooper (17–6) || — || — || 60–35
|- bgcolor="ccffcc" | 96 || August 1 || Braves || 7–3 || Adams (11–3) || McQuillan || — || — || 61–35 |- bgcolor="ccffcc" | 97 || August 3 || Phillies || 9–5 || Cooper (18–6) || Winters || — || — || 62–35 |- bgcolor="ccffcc" | 98 || August 4 || Phillies || 5–0 || Hamilton (9–10) || Meadows || — || — || 63–35 |- bgcolor="ccffcc" | 99 || August 5 || Phillies || 8–5 || Zinn (5–4) || Ring || — || — || 64–35 |- bgcolor="ffbbbb" | 100 || August 6 || Robins || 2–3 || Cadore || Glazner (9–4) || — || 18,000 || 64–36 |- bgcolor="ffbbbb" | 101 || August 8 || Robins || 2–4 || Grimes || Cooper (18–7) || — || 8,000 || 64–37 |- bgcolor="ccffcc" | 102 || August 9 || Robins || 4–2 || Adams (12–3) || Mitchell || Zinn (4) || 8,000 || 65–37 |- bgcolor="ffbbbb" | 103 || August 10 || Robins || 0–1 || Cadore || Morrison (3–3) || — || 6,000 || 65–38 |- bgcolor="ccffcc" | 104 || August 11 || Cubs || 7–3 || Hamilton (10–10) || Alexander || — || — || 66–38 |- bgcolor="ccffcc" | 105 || August 11 || Cubs || 5–4 (11) || Zinn (6–4) || Martin || — || — || 67–38 |- bgcolor="ccffcc" | 106 || August 12 || Cubs || 12–9 || Cooper (19–7) || Cheeves || — || — || 68–38 |- bgcolor="ccffcc" | 107 || August 13 || Cubs || 4–3 || Glazner (10–4) || Freeman || — || — || 69–38 |- bgcolor="ccffcc" | 108 || August 14 || @ Cubs || 1–0 || Morrison (4–3) || Martin || — || — || 70–38 |- bgcolor="ffbbbb" | 109 || August 16 || @ Phillies || 5–6 || Betts || Cooper (19–8) || — || — || 70–39 |- bgcolor="ccffcc" | 110 || August 16 || @ Phillies || 8–6 (11) || Zinn (7–4) || Smith || — || — || 71–39 |- bgcolor="ccffcc" | 111 || August 18 || @ Phillies || 4–3 || Hamilton (11–10) || Ring || Carlson (2) || — || 72–39 |- bgcolor="ccffcc" | 112 || August 18 || @ Phillies || 3–2 || Glazner (11–4) || Winters || — || — || 73–39