USS Otsego may refer to the following ships of the United States Navy:
, was a small schooner obtained on loan from the Army in 1840 for action against the Seminole Indians , was a gunboat commissioned in the spring of 1864 was a light draft monitor originally which was renamed Hydra in 1869 and Ostego? later that year was a passenger-cargo steamship built in Germany in 1902 as Prinz Eitel Friedrich which in 1919 served as the troop transport USS Otsego (ID-1628)