Guanahacabibes is a word of Taíno origin, and may refer to the following places in Cuba:
Guanahacabibes Peninsula, a peninsula in the western extremity of Cuba Gulf of Guanahacabibes, a gulf north of the peninsula Guanahacabibes Biosphere Reserve, a protected area on the peninsula
See also Eleutherodactylus guanahacabibes, a species of frog in the family Eleutherodactylidae, named for the Guanahacabibes Peninsula Guanahacabibes dwarf boa (Tropidophis xanthogaster), a species of snake endemic to the Guanahacabibes Peninsula